Does theophylline really improve acute mountain sickness?

Does theophylline really improve acute mountain sickness?

Fischer et al. [1] report that theophylline improves acute mountain sickness (AMS). This is of high interest, as there may be an adenosine-sensitive mechanism of hypoxic respiratory control and therapy, with a specific adenosine antagonist like theophylline, which may potentially influence respiratory adaptation to hypoxia. However, recent studies in human and animal experiments, which sought t...

Theophylline improves acute mountain sickness.

A randomized two-part study was conducted in order to determine the efficacy of theophylline in the treatment of acute mountain sickness during fast ascent to altitudes >2,500 m. Fourteen healthy male subjects participated in a randomized single-blind placebo-controlled crossover study carried out in a decompression chamber (simulated altitude 4,500 m). A second randomized single-blind, placebo...

The prevention of acute mountain sickness – the effect of theophylline and acetazolamide in prevention of acute mountain sickness

Severe acute mountain sickness.

The experiences of acute mountain sickness (AMS) as it has presented to a physician working in a general hospital at 1370 m in Kathmandu, nepal, are described. The features of 39 cases are analysed. It is suggested that AMS should be classified into benign and malignant forms.

Acute mountain sickness.

Acute mountain sickness (AMS) is a clinical syndrome occurring in otherwise healthy normal individuals who ascend rapidly to high altitude. Symptoms develop over a period ofa few hours or days. The usual symptoms include headache, anorexia, nausea, vomiting, lethargy, unsteadiness of gait, undue dyspnoea on moderate exertion and interrupted sleep. AMS is unrelated to physical fitness, sex or ag...